The second leg in Busch's triple duty at Kentucky is Friday night's 300-mile Nationwide Series race. Busch topped the charts in Thursday's practice session but placed 11th in final practice, held on Friday morning. NASCAR gave Nationwide teams a full-day of testing at this 1.5-mile track on Wednesday.
The 400-mile Sprint Cup Series race at Kentucky is scheduled for Saturday night.
In August 2010, Busch won all three NASCAR races at Bristol on the same week, becoming the first driver in the history of the sport to accomplish that feat.
When all three series competed at Dover four weeks ago, Busch won the Camping World Truck and Nationwide events but finished 42nd in the Sprint Cup race after he was involved in an accident in the early going.
Can he pull off the trifecta at Kentucky?
"I think so," Busch told Fox Sports 1 during his victory lane interview in the Truck Series race at Kentucky. "My Nationwide car wasn't great [in Wednesday's test session], but we made whole sale changes to it and got it a lot better here for this practice that happened before the truck race. My chances are there, and I hope it comes true."
Busch won the inaugural Sprint Cup race at Kentucky in 2011. He also has one Nationwide victory here, occurring in 2004.
"I love Kentucky," he said. "It's a pretty challenging racetrack. It's a place that lends itself to different kinds of setups because it's so rough. Fast lap times at Kentucky come from momentum. The place is so round that there's not a ton of banking compared to some other 1.5-milers. It's all about how round the corners are and just being able to maintain corner speed and stay on the gas."
Busch holds the record for most career Nationwide wins with 66. Three of those victories have come this season -- Phoenix, Bristol and Dover.
Forty-four teams are on the entry list for the John R. Elliott HERO Campaign 300.
Series: NASCAR Nationwide. Date: Friday, June 27. Race: John R. Elliott HERO Campaign 300. Site: Kentucky Speedway. Track: 1.5-mile oval. Start time: 7:30 p.m. ET. Laps: 200. Miles: 300. 2013 Winner: Brad Keselowski. Television: ESPN. Radio: Performance Racing Network (PRN)/SIRIUS NASCAR Radio.