WebMD Medical News
Daniel J. DeNoon
Louise Chang, MD
Jan. 26, 2007 -- An anesthetic spray more than doubles the "lasting"
time for men with premature ejaculation, according to a study by the company
that makes the experimental spray.
The metered-dose, aerosol spray is a mixture of the anesthetics lidocaine
and prilocaine. It is spritzed onto the tip of the penis 15 minutes before
Before using the spray, the 54 heterosexual men in the study ejaculated, on
average, one minute after vaginal penetration.
In the test, on four occasions, half the men used the anesthetic spray 15
minutes before sex, the other half a placebo with no active ingredients.
The men or their partners used a stopwatch to measure the time from vaginal
penetration to ejaculation.
Premature ejaculation isn't defined by a specific time until ejaculation.
According to the Diagnostic and Statistical Manual of Mental Disorders IV
(DSM-IV), premature ejaculation is "persistent or recurrent ejaculation
with minimal sexual stimulation before, on, or shortly after penetration and
before the person wishes it."
About 70% of men who used the spray and just under 50% of the men who used
the placebo said they had longer time to ejaculation.
About 60% of the female partners of men who used the spray, and about 30% of
the partners of the men who used the placebo, said the men had better control
over their ejaculation.
The spray is called TEMPE -- topical eutectic mixture for premature
ejaculation -- by manufacturer Plethora Solutions Ltd. London, which funded the
study. It is not yet available on the market.
"TEMPE 'as required' has the potential to offer a convenient, novel
treatment option for men with premature ejaculation," conclude researchers
Wallace C. Dinsmore, MD, of Royal Victoria Hospital, Belfast, Northern Ireland,
The spray had few side effects.
Four of the 26 men who used TEMPE did report side effects. Three had
numbness of the penis, and one reported erectile dysfunction.
Only one of the men's sex partners reported a side effect: a mild burning
sensation during intercourse.
Emla, from AstraZeneca, is also a mixture of lidocaine and prilocaine. It
comes in a cream formulation and must be used with a condom. TEMPE does not
require condom use.
The study appears in the February issue of the urology journal BJU
SOURCES: Dinsmore, W. BJU International, February 2007; vol 99: pp
369-375. Diagnostic and Statistical Manual of Mental Disorders, Fourth
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